diff --git a/code/modules/reagents/chemistry/reagents/cat2_medicine_reagents.dm b/code/modules/reagents/chemistry/reagents/cat2_medicine_reagents.dm
index 302b2c9fe8aa4..5b9d87e96c625 100644
--- a/code/modules/reagents/chemistry/reagents/cat2_medicine_reagents.dm
+++ b/code/modules/reagents/chemistry/reagents/cat2_medicine_reagents.dm
@@ -497,13 +497,15 @@
 		show_message = 0
 	if(!(methods & (PATCH|TOUCH|VAPOR)))
 		return
-	var/harmies = min(carbies.getBruteLoss(), carbies.adjustBruteLoss(-1.25 * reac_volume, updating_health = FALSE, required_bodytype = affected_bodytype)*-1)
-	var/burnies = min(carbies.getFireLoss(), carbies.adjustFireLoss(-1.25 * reac_volume, updating_health = FALSE, required_bodytype = affected_bodytype)*-1)
+	var/current_bruteloss = carbies.getBruteLoss() // because this will be changed after calling adjustBruteLoss()
+	var/current_fireloss = carbies.getFireLoss() // because this will be changed after calling adjustFireLoss()
+	var/harmies = clamp(carbies.adjustBruteLoss(-1.25 * reac_volume, updating_health = FALSE, required_bodytype = affected_bodytype), 0, current_bruteloss)
+	var/burnies = clamp(carbies.adjustFireLoss(-1.25 * reac_volume, updating_health = FALSE, required_bodytype = affected_bodytype), 0, current_fireloss)
 	for(var/i in carbies.all_wounds)
 		var/datum/wound/iter_wound = i
 		iter_wound.on_synthflesh(reac_volume)
 	var/need_mob_update = harmies + burnies
-	need_mob_update += carbies.adjustToxLoss((harmies+burnies)*(0.5 + (0.25*(1-creation_purity))), updating_health = FALSE, required_biotype = affected_biotype) //0.5 - 0.75
+	need_mob_update = carbies.adjustToxLoss((harmies + burnies)*(0.5 + (0.25*(1-creation_purity))), updating_health = FALSE, required_biotype = affected_biotype) || need_mob_update //0.5 - 0.75
 
 	if(need_mob_update)
 		carbies.updatehealth()