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GI-HCC.html
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<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
<html>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
<title>HCC</title>
<link rel="stylesheet" type="text/css" href="view.css" media="all">
<script type="text/javascript" src="view.js"></script>
<script>
function updateDescription (frm)
{
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if (frm.A09.value !== ""){
Template += "- Satellitosis: " + frm.A09.value + "\n";
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/**
if (frm.A10.value !== ""){
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**/
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Template += "- Vascular invasion: " + frm.A11.value + "\n";
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if (frm.A16.value !== ""){
Template += " - Number of regional lymph nodes examined: " + frm.A16.value + "\n";
}
if (frm.A17.value !== ""){
Template += " - Number of lymph nodes involved: " + frm.A17.value + "\n";
}
if (frm.A18.value !== ""){
Template += " - Extranodal extension (ENE) : " + frm.A18.value + "\n";
}
if (frm.A19.value !== ""){
Template += " - Size of largest metastatic deposit (mm), specify site: " + frm.A19.value + "\n";
}
if (frm.A20.value !== ""){
Template += " - Size of largest lymph node involved (mm), specify site: " + frm.A20.value + "\n";
}
if (document.getElementById("A38").checked || document.getElementById("A39").checked ||
document.getElementById("A40").checked || document.getElementById("A41").checked ||
document.getElementById("A42").checked || document.getElementById("A43").checked ){
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}
if (document.getElementById("A38").checked){
Template += frm.A38.value + "\n";
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document.getElementById("A23").checked ||
frm.A24.value + frm.A25.value + frm.A26.value !== ""){
Template += "\n" + "- Pathologic stage classification (pTNM, AJCC 8th edition):" + "\n";
}
if (document.getElementById("A21").checked || document.getElementById("A22").checked ||
document.getElementById("A23").checked){
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**/
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frm.A36.value !==""){
Template += "\n" + "- Additional pathologic findings: " + "\n";
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</script>
<style>
table, th, td {
border: 1px solid silver;
border-collapse: collapse;
padding: 4px;
}
</style>
</head>
<body>
<img id="top" src="top.png" alt="">
<div id="form_container">
<div class="form_description">
<h2><a href=".\cap\Cancer-Protocols-2022-06-Update\Gastrointestinal Protocol Folder\Liver.HCC_4.3.0.0.REL_CAPCP.pdf" target="_blank">
<div class="tooltip">
Hepatocellular carcinoma
<span class="tooltiptext">click to access explanations in the original CAP template</span>
</div>
<a></h2>
</div>
<form>
<!--
<p>
<fieldset style="border-color:#e6e6ff;">
<legend><label class="description">Gross descriptions:</label></legend>
<p>
<table border="1">
<col width="40%">
<tr>
<td>
<label class="description">- Procedure:</label>
</td>
<td>
<select class="element select large" ID="A01">
<option value=""></option>
<option value=" - Wedge resection">Wedge resection</option>
<option value=" - Partial hepatectomy">Partial hepatectomy</option>
<option value=" - Partial hepatectomy , Major hepatectomy (3 segments or more)">Partial hepatectomy , Major hepatectomy (3 segments or more)</option>
<option value=" - Partial hepatectomy , Minor hepatectomy (less than 3 segments)">Partial hepatectomy , Minor hepatectomy (less than 3 segments)</option>
<option value=" - Total hepatectomy">Total hepatectomy</option>
<option value=" - Other (specify):">Other (specify):</option>
<option value=" - Not specified">Not specified</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Tumor focality:</label>
</td>
<td>
<select class="element select large" ID="A02">
<option value=""></option>
<option value=" - Solitary">Solitary</option>
<option value=" - Multiple">Multiple</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Tumor site:</label>
</td>
<td>
<select class="element select large" ID="A03">
<option value=""></option>
<option value=" - Right lobe">Right lobe</option>
<option value=" - Left lobe">Left lobe</option>
<option value=" - Caudate lobe">Caudate lobe</option>
<option value=" - Quadrate lobe">Quadrate lobe</option>
<option value=" - Segmental location (specify):">Segmental location (specify):</option>
<option value=" - Other (specify):">Other (specify):</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Tumor size:</label>
</td>
<td>
<select class="element select large" ID="A04">
<option value=""></option>
<option value=" - Greatest dimension (mm): ">Greatest dimension (mm): </option>
<option value=" - All dimensions (mm x mm x mm): ">All dimensions (mm x mm x mm):</option>
<option value=" - Cannot be determined (explain):">Cannot be determined (explain):</option>
</select>
</td>
</tr>
</table>
</p>
</fieldset>
</p>
-->
<p>
<fieldset style="border-color:#e6e6ff;">
<legend><label class="description">Microscopic descriptions:</label></legend>
<p><label class="description">- Tumor histology and immunohistochemical studies: </label>
<textarea ID="A05" class="element textarea medium"></textarea>
</p>
<p>
<table border="1">
<col width="40%">
<tr>
<td>
<label class="description">- <a href=".\cap\Cancer-Protocols-2021-06-Update\Gastrointestinal-Protocol-Folder\Liver.HCC_4.2.0.0.REL_CAPCP.pdf#page=8" target="_blank">Histologic type (WHO 2019)</a>:</label>
</td>
<td>
<select class="element select large" ID="A06">
<option value=""></option>
<option value=""></option>
<option value="Hepatocellular carcinoma">Hepatocellular carcinoma</option>
<option value="Hepatocellular carcinoma, fibrolamellar">Hepatocellular carcinoma, fibrolamellar</option>
<option value="Hepatocellular carcinoma, scirrhous">Hepatocellular carcinoma, scirrhous</option>
<option value="Hepatocellular carcinoma, clear cell type">Hepatocellular carcinoma, clear cell type</option>
<option value="Other histologic type not listed (specify):">Other histologic type not listed (specify):</option>
<option value="Carcinoma, type cannot be determined">Carcinoma, type cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- <a href=".\cap\Cancer-Protocols-2021-06-Update\Gastrointestinal-Protocol-Folder\Liver.HCC_4.2.0.0.REL_CAPCP.pdf#page=9" target="_blank">Histologic grade</a>:</label>
</td>
<td>
<select class="element select large" ID="A07">
<option value=""></option>
<option value="G1: Well differentiated">G1: Well differentiated</option>
<option value="G2: Moderately differentiated">G2: Moderately differentiated</option>
<option value="G3: Poorly differentiated">G3: Poorly differentiated</option>
<option value="G4: Undifferentiated">G4: Undifferentiated</option>
<option value="GX: Cannot be assessed">GX: Cannot be assessed</option>
<option value="Other (specify):">Other (specify):</option>
<option value="Not applicable">Not applicable</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Tumor extension:</label>
</td>
<td>
<select class="element select large" ID="A08">
<option value=""></option>
<option value="Tumor confined to liver">Tumor confined to liver</option>
<option value="Tumor involves a major branch of the portal vein">Tumor involves a major branch of the portal vein</option>
<option value="Tumor involves hepatic vein(s)">Tumor involves hepatic vein(s)</option>
<option value="Tumor involves (perforates) visceral peritoneum">Tumor involves (perforates) visceral peritoneum</option>
<option value="Tumor directly invades gallbladder">Tumor directly invades gallbladder</option>
<option value="Tumor directly invades diaphragm">Tumor directly invades diaphragm</option>
<option value="Tumor directly invades other adjacent organs (specify):">Tumor directly invades other adjacent organs (specify):</option>
<option value="Cannot be assessed">Cannot be assessed</option>
<option value="No evidence of primary tumor">No evidence of primary tumor</option>
</select>
</td>
</tr>
<tr>
<td>
<label class=""> + Satellitosis: </label>
</td>
<td>
<select class="element select large" ID="A09">
<option value=""></option>
<option value="Not identified">Not identified</option>
<option value="Present">Present</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<!--
<tr>
<td>
<label class="description">- <a href=".\cap\Cancer-Protocols-2021-06-Update\Gastrointestinal-Protocol-Folder\Liver.HCC_4.2.0.0.REL_CAPCP.pdf#page=10" target="_blank">Lymphovascular invasion</a>: </label>
</td>
<td>
<select class="element select large" ID="A10">
<option value=""></option>
<option value="Not identified">Not identified</option>
<option value="Present">Present</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
-->
<tr>
<td>
<label class="description">- <a href=".\cap\Cancer-Protocols-2021-06-Update\Gastrointestinal-Protocol-Folder\Liver.HCC_4.2.0.0.REL_CAPCP.pdf#page=11" target="_blank">Vascular invasion (specify the tumor nodule, if applicable)</a>: </label>
</td>
<td>
<select class="element select large" ID="A11">
<option value=""></option>
<option value="Not identified">Not identified</option>
<option value="Present, small vessel invasion">Present, small vessel invasion</option>
<option value="Present, large vessel invasion (major branch of hepatic vein or portal vein)">Present, large vessel invasion (major branch of hepatic vein or portal vein)</option>
<option value="Present (not otherwise specified)">Present (not otherwise specified)</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="">+ Perineural invasion: </label>
</td>
<td>
<select class="element select large" ID="A12">
<option value=""></option>
<option value="Not identified">Not identified</option>
<option value="Present">Present</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Treatment effect: </label>
</td>
<td>
<select class="element select large" ID="A13">
<option value=""></option>
<option value="No known presurgical therapy">No known presurgical therapy</option>
<option value="Complete necrosis (no viable tumor)">Complete necrosis (no viable tumor)</option>
<option value="Incomplete necrosis (viable tumor present), specify tumor necrosis %:">Incomplete necrosis (viable tumor present), specify tumor necrosis %:</option>
<option value="No necrosis">No necrosis</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
</table>
</p>
<p>
<a href=".\cap\HCC_WHO2019.png" target="_blank"><img src=".\cap\HCC_WHO2019.png" alt="Risk assessment" width="600">Liang et al 2022</a>.
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend><label class="description">Surgical margins:</label></legend>
<p>
<table border="1">
<col width="40%">
<tr>
<td>
<label class="description">- <a href=".\cap\Cancer-Protocols-2021-06-Update\Gastrointestinal-Protocol-Folder\Liver.HCC_4.2.0.0.REL_CAPCP.pdf#page=11" target="_blank">Parenchymal margin</a>:</label>
</td>
<td>
<select class="element select large" ID="A14">
<option value=""></option>
<option value="Cannot be assessed">Cannot be assessed</option>
<option value="Involved by invasive carcinoma">Involved by invasive carcinoma</option>
<option value="Uninvolved by invasive carcinoma, specify distance (mm):">Uninvolved by invasive carcinoma, specify distance (mm):</option>
</select>
</td>
</tr>
<tr>
<td>
<label>- Other margin(s) (specify: ):</label>
</td>
<td>
<select class="element select large" ID="A15">
<option value=""></option>
<option value="Cannot be assessed">Cannot be assessed</option>
<option value="Involved by invasive carcinoma">Involved by invasive carcinoma</option>
<option value="Uninvolved by invasive carcinoma, specify distance (mm):">Uninvolved by invasive carcinoma, specify distance (mm):</option>
</select>
</td>
</tr>
</table>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class="description"> Regional lymph nodes: </label></legend>
<p>
<table border="1">
<col width="75%">
<tr>
<td>
<label class="description">- Number of regional lymph nodes examined:</label>
</td>
<td>
<input type="text" class="element text large" ID="A16">
</td>
</tr>
<tr>
<td>
<label class="description">- Number of lymph nodes involved:</label>
</td>
<td>
<input type="text" class="element text large" ID="A17">
</td>
</tr>
<tr>
<td>
<label class="description">- Extranodal extension:</label>
</td>
<td>
<select class="element select large" ID="A18">
<option value=""></option>
<option value="Not identified">Not identified</option>
<option value="Present">Present</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Size of largest metastatic deposit (mm), specify site:</label>
</td>
<td>
<input type="text" class="element text large" ID="A19">
</td>
</tr>
<tr>
<td>
<label class="description">- Size of largest lymph node involved (mm), specify site:</label>
</td>
<td>
<input type="text" class="element text large" ID="A20">
</td>
</tr>
</table>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class="description"> Distant Metastasis: </label></legend>
<input class="element checkbox" type="checkbox" id="A38" value=" - Not applicable"><label class="choice" >Not applicable</label>
<input class="element checkbox" type="checkbox" id="A39" value=" - Not identified"><label class="choice" >Not identified</label>
<input class="element checkbox" type="checkbox" id="A40" value=" - Non-regional lymph node(s) (specify):"><label class="choice" >Non-regional lymph node(s) (specify):</label>
<input class="element checkbox" type="checkbox" id="A41" value=" - Liver (specify):"><label class="choice" >Liver (specify):</label>
<input class="element checkbox" type="checkbox" id="A42" value=" - Other (specify):"><label class="choice" >Other (specify):</label>
<input class="element checkbox" type="checkbox" id="A43" value=" - Cannot be determined: "><label class="choice" >Cannot be determined: </label>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class="description"> Pathologic Stage Classification (AJCC 8e):</label></legend>
<p>
<table border="1">
<col width="40%">
<tr>
<td valign="top">
<label class="description">- TNM Descriptors:</label>
</td>
<td>
<input class="element checkbox" type="checkbox" id="A21" value=" m (multiple primary tumors) "><label class="choice"> m (multiple primary tumors)</label>
<input class="element checkbox" type="checkbox" id="A22" value=" r (recurrent) "><label class="choice"> r (recurrent)</label>
<input class="element checkbox" type="checkbox" id="A23" value=" y (post treatment) "><label class="choice"> y (post treatment)</label>
</td>
</tr>
<tr>
<td>
<label class="description">- <a href=".\cap\Cancer-Protocols-2021-06-Update\Gastrointestinal-Protocol-Folder\Liver.HCC_4.2.0.0.REL_CAPCP.pdf#page=13" target="_blank">Primary tumor (pT)</a>:</label>
</td>
<td>
<select class="element select large" ID="A24">
<option value=""></option>
<option value=" - pT not assigned (cannot be determined based on available pathological information)"> pT not assigned (cannot be determined based on available pathological information)</option>
<option value=" - pT0: No evidence of primary tumor">pT0: No evidence of primary tumor</option>
<option value=" - pT1: Solitary tumor < or = 2 cm, or > 2 cm without vascular invasion">pT1: Solitary tumor < or = 2 cm, or > 2 cm without vascular invasion</option>
<option value=" - pT1a: Solitary tumor < or = 2 cm">pT1a: Solitary tumor < or = 2 cm</option>
<option value=" - pT1b: Solitary tumor >2 cm without vascular invasion">pT1b: Solitary tumor >2 cm without vascular invasion</option>
<option value=" - pT2: Solitary tumor > 2 cm with vascular invasion, or multiple tumors, none > 5 cm">pT2: Solitary tumor > 2 cm with vascular invasion, or multiple tumors, none > 5 cm</option>
<option value=" - pT3: Multiple tumors, at least one of which is > 5 cm">pT3: Multiple tumors, at least one of which is > 5 cm</option>
<option value=" - pT4: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein, or tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum">pT4: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein, or tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- <a href=".\cap\Cancer-Protocols-2021-06-Update\Gastrointestinal-Protocol-Folder\Liver.HCC_4.2.0.0.REL_CAPCP.pdf#page=14" target="_blank">Regional lymph nodes (pN)</a>: </label>
</td>
<td>
<select class="element select large" ID="A25">
<option value=""></option>
<option value=" - pN not assigned (no nodes submitted or found)">pN not assigned (no nodes submitted or found)</option>
<option value=" - pN not assigned (cannot be determined based on available pathological information)">pN not assigned (cannot be determined based on available pathological information)</option>
<option value=" - pN0: No regional lymph node metastasis">pN0: No regional lymph node metastasis</option>
<option value=" - pN1: Regional lymph node metastasis">pN1: Regional lymph node metastasis</option>
<select>
</td>
</tr>
<tr>
<td>
<label class="description">- Distant metastasis (pM): </label>
</td>
<td>
<select class="element select large" ID="A26">
<option value=""></option>
<option value=" - Not applicable - pM cannot be determined from the submitted specimen(s)">Not applicable - pM cannot be determined from the submitted specimen(s)</option>
<option value=" - pM1: Distant metastasis">pM1: Distant metastasis</option>
</select>
</td>
</tr>
<!--
<tr>
<td>
<label>- Specify site(s), if known:</label>
<input type="text" class="element text small" ID="A27" size="35">
</td>
</tr>
-->
</table>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class=""> + Additional pathologic findings: </label></legend>
<p>
<input class="element checkbox" type="checkbox" id="A28" value=" - Fibrosis (specify extent, providing name of the scheme and assessment scale used): "><label class="choice">Fibrosis (specify extent, providing name of the scheme and assessment scale used): </label>
<input class="element checkbox" type="checkbox" id="A29" value=" - Cirrhosis"><label class="choice">Cirrhosis</label>
<input class="element checkbox" type="checkbox" id="A30" value=" - Low-grade dysplastic nodule"><label class="choice">Low-grade dysplastic nodule</label>
<input class="element checkbox" type="checkbox" id="A31" value=" - High-grade dysplastic nodule"><label class="choice">High-grade dysplastic nodule</label>
<input class="element checkbox" type="checkbox" id="A32" value=" - Steatosis"><label class="choice">Steatosis</label>
<input class="element checkbox" type="checkbox" id="A33" value=" - Steatohepatitis"><label class="choice">Steatohepatitis</label>
<input class="element checkbox" type="checkbox" id="A34" value=" - Iron overload"><label class="choice">Iron overload</label>
<input class="element checkbox" type="checkbox" id="A35" value=" - Chronic hepatitis (specify etiology): "><label class="choice">Chronic hepatitis (specify etiology): </label>
<p>- Other (specify):
<input type="text" class="element text medium" ID="A36" size="35">
</p>
<br>
</fieldset>
</p>
<p>
<label class="description">- Additional notes:</label>
<textarea ID="A37" class = "element textarea medium" style="border-color:Grey;"></textarea>
</p>
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Last upated on 18-Dec-2024, <br>
based on <a href="https://www.cap.org/protocols-and-guidelines/cancer-reporting-tools/cancer-protocol-templates" target="_blank">US CAP cancer protocol templates</a>.<br>
Version: Hepatocellular 4.3.0.0 (June 2022),
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Anatomical Pathology Division, Queen Mary Hospital, Hong Kong.
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