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HN-Lip and oral cavity.html
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<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
<title>Cancers of the oral cavity</title>
<link rel="stylesheet" type="text/css" href="view.css" media="all">
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<style>
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border: 1px solid silver;
border-collapse: collapse;
padding: 4px;
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</head>
<body>
<img id="top" src="top.png" alt="">
<div id="form_container">
<div class="form_description">
<h2>
<a href=".\cap\Cancer-Protocols-2023-06-Update\Head and Neck Protocol Folder\HN.Oral_4.2.0.0.REL_CAPCP.pdf" target="_blank">
<div class="tooltip">
Cancers of the oral cavity
<span class="tooltiptext">click to access explanations in the original CAP template</span>
</div>
</a>
</h2>
</div>
<p>
Please also refer to <a href=".\cap\Cancer-Protocols-2021-11-Update\HN.Bmk_2.0.0.1.REL_CAPCP.pdf" target="_blank">H&N biomarker protocol (HeadNeckBiomarkers 2.0.0.0, June-2021)</a> for possible ancillary testings.
</p>
<form>
<!--
<p>
<fieldset style="border-color:#e6e6ff;">
<legend><label class="description">Gross descriptions:</label></legend>
<p>
<table border="1">
<col width="40%">
<tr>
<td>
<label class="description">- Procedure:</label>
</td>
<td>
<select class="element select large" ID="A01">
<option value=""></option>
<option value=" - Excision">Excision</option>
<option value=" - Glossectomy (specify):">Glossectomy (specify):</option>
<option value=" - Buccal mucosal resection (specify):">Buccal mucosal resection (specify):</option>
<option value=" - Mandibulectomy (specify):">Mandibulectomy (specify):</option>
<option value=" - Maxillectomy (specify):">Maxillectomy (specify):</option>
<option value=" - Palatectomy">Palatectomy</option>
<option value=" - Neck (lymph node) dissection (specify):">Neck (lymph node) dissection (specify):</option>
<option value=" - Other (specify):">Other (specify):</option>
<option value=" - Not specified">Not specified</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Tumor site:</label>
</td>
<td>
<select class="element select large" ID="A02">
<option value=""></option>
<option value=" - Lip">Lip</option>
<option value=" - Lip, mucosa of upper lip">Lip, mucosa of upper lip</option>
<option value=" - Lip, Mucosa of lower lip">Lip, Mucosa of lower lip</option>
<option value=" - Oral cavity">Oral cavity</option>
<option value=" - Oral cavity, lateral border of tongue">Oral cavity, lateral border of tongue</option>
<option value=" - Oral cavity, ventral surface of tongue">Oral cavity, ventral surface of tongue</option>
<option value=" - Oral cavity, dorsal surface of tongue">Oral cavity, dorsal surface of tongue</option>
<option value=" - Oral cavity, anterior two-thirds of tongue">Oral cavity, anterior two-thirds of tongue</option>
<option value=" - Oral cavity, upper gingiva">Oral cavity, upper gingiva</option>
<option value=" - Oral cavity, lower gingiva">Oral cavity, lower gingiva</option>
<option value=" - Oral cavity, anterior floor of mouth">Oral cavity, anterior floor of mouth</option>
<option value=" - Oral cavity, floor of mouth">Oral cavity, floor of mouth</option>
<option value=" - Oral cavity, hard palate">Oral cavity, hard palate</option>
<option value=" - Oral cavity, buccal mucosa">Oral cavity, buccal mucosa</option>
<option value=" - Oral cavity, vestibule of mouth, maxillary">Oral cavity, vestibule of mouth, maxillary</option>
<option value=" - oral cavity, vestibule of mouth, mandibular">oral cavity, vestibule of mouth, mandibular</option>
<option value=" - Oral cavity, alveolar process, maxillary">Oral cavity, alveolar process, maxillary</option>
<option value=" - Oral cavity, alveolar process, mandibular">Oral cavity, alveolar process, mandibular</option>
<option value=" - Oral cavity, retromolar area">Oral cavity, retromolar area</option>
<option value=" - Other (specify):">Other (specify):</option>
<option value=" - Not specified">Not specified</option>
</select>
</td>
</tr>
<tr>
<td valign="top">
<label class="description">- Tumor laterality:</label>
</td>
<td>
<input class="element checkbox" type="checkbox" id="A03" value=" - Right"><label >Right</label><br>
<input class="element checkbox" type="checkbox" id="A04" value=" - Left"><label >Left</label><br>
<input class="element checkbox" type="checkbox" id="A05" value=" - Midline"><label >Midline</label><br>
<input class="element checkbox" type="checkbox" id="A06" value=" - Not specified"><label >Cannot be determined (explain):</label><br>
</td>
</tr>
<tr>
<td>
<label class="description">- Tumor focality:</label>
</td>
<td>
<select class="element select large" ID="A07">
<option value=""></option>
<option value=" - Unifocal">Unifocal</option>
<option value=" - Multifocal">Multifocal</option>
<option value=" - Cannot be determined (explain):">Cannot be determined (explain):</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Tumor size:</label>
</td>
<td>
<select class="element select large" ID="A08">
<option value=""></option>
<option value=" - Greatest dimension (mm): ">Greatest dimension (mm): </option>
<option value=" - All dimensions (mm x mm x mm): ">All dimensions (mm x mm x mm):</option>
<option value=" - Cannot be determined (explain): ">Cannot be determined (explain):</option>
</select>
</td>
</tr>
</table>
</p>
</fieldset>
</p>
-->
<p>
<fieldset style="border-color:#e6e6ff;">
<legend><label class="description">Microscopic descriptions:</label></legend>
<p>
<label class="description">- Tumor histology and immunohistochemical studies: </label>
<textarea ID="A09" class="element textarea medium"></textarea>
</p>
<p>
<table border="1">
<col width="40%">
<tr>
<td valign="top">
<label class="description">- <a href=".\cap\Cancer-Protocols-2023-06-Update\Head and Neck Protocol Folder\HN.Oral_4.2.0.0.REL_CAPCP.pdf#page=18" target="_blank">SCC and variants (WHO 5e)</a> :</label>
</td>
<td>
<input class="element checkbox" type="checkbox" id="A10" value=" - Squamous cell carcinoma, conventional (keratinizing)"><label class="choice">Squamous cell carcinoma, conventional (keratinizing)</label>
<input class="element checkbox" type="checkbox" id="A11" value=" - Squamous cell carcinoma, nonkeratinizing"><label class="choice">Squamous cell carcinoma, nonkeratinizing</label>
<input class="element checkbox" type="checkbox" id="A12" value=" - Adenosquamous carcinoma"><label class="choice">Adenosquamous carcinoma</label>
<input class="element checkbox" type="checkbox" id="A13" value=" - Basaloid squamous cell carcinoma"><label class="choice">Basaloid squamous cell carcinoma</label>
<input class="element checkbox" type="checkbox" id="A15" value=" - Papillary squamous cell carcinoma"><label class="choice">Papillary squamous cell carcinoma</label>
<input class="element checkbox" type="checkbox" id="A16" value=" - Spindle cell squamous cell carcinoma"><label class="choice">Spindle cell squamous cell carcinoma</label>
<input class="element checkbox" type="checkbox" id="A17" value=" - Verrucous squamous cell carcinoma"><label class="choice">Verrucous squamous cell carcinoma</label>
<input class="element checkbox" type="checkbox" id="A14" value=" - Carcinoma cuniculatum"><label class="choice">Carcinoma cuniculatum</label>
<input class="element checkbox" type="checkbox" id="A18" value=" - Lymphoepithelial carcinoma (non-nasopharyngeal)"><label class="choice">Lymphoepithelial carcinoma (non-nasopharyngeal)</label>
</td>
<tr>
<tr>
<td>
<label class="description">- Minor salivary glands CA :</label>
</td>
<td>
<select class="element select large" ID="A19">
<option value=""></option>
<option value="Carcinoma ex pleomorphic adenoma, minimally invasive + malignant component">Carcinoma ex pleomorphic adenoma, minimally invasive + malignant component</option>
<option value="Carcinoma ex pleomorphic adenoma, invasive + malignant component">Carcinoma ex pleomorphic adenoma, invasive + malignant component</option>
<option value="Carcinoma ex pleomorphic adenoma, intracapsular (noninvasive) + malignant component">Carcinoma ex pleomorphic adenoma, intracapsular (noninvasive) + malignant component</option>
<option value="Carcinoma ex pleomorphic adenoma, extent cannot be determined + malignant component">Carcinoma ex pleomorphic adenoma, extent cannot be determined + malignant component</option>
<option value="Mucoepidermoid carcinoma, low grade">Mucoepidermoid carcinoma, low grade</option>
<option value="Mucoepidermoid carcinoma, intermediate grade">Mucoepidermoid carcinoma, intermediate grade</option>
<option value="Mucoepidermoid carcinoma, high grade">Mucoepidermoid carcinoma, high grade</option>
<option value="Adenoid cystic carcinoma, tubular pattern, specify percentage of solid component:">Adenoid cystic carcinoma, tubular pattern, specify percentage of solid component:</option>
<option value="Adenoid cystic carcinoma, cribriform pattern, specify percentage of solid component:">Adenoid cystic carcinoma, cribriform pattern, specify percentage of solid component:</option>
<option value="Adenoid cystic carcinoma, solid pattern, specify percentage of solid component:">Adenoid cystic carcinoma, solid pattern, specify percentage of solid component:</option>
<option value="Acinic cell carcinoma">Acinic cell carcinoma</option>
<option value="Secretory carcinoma">Secretory carcinoma</option>
<option value="Polymorphous adenocarcinoma, conventional">Polymorphous adenocarcinoma, conventional</option>
<option value="Polymorphous adenocarcinoma, cribriform subtype (% papillary and cribriform components)">Polymorphous adenocarcinoma, cribriform subtype (% papillary and cribriform components)</option>
<option value="Salivary duct carcinoma">Salivary duct carcinoma</option>
<option value="Epithelial-myoepithelial carcinoma">Epithelial-myoepithelial carcinoma</option>
<option value="Hyalinizing clear cell carcinoma">Hyalinizing clear cell carcinoma</option>
<option value="Microsecretory adenocarcinoma">Microsecretory adenocarcinoma</option>
<option value="Intraductal carcinoma (specify subtype):">Intraductal carcinoma (specify subtype):</option>
<option value="Basal cell adenocarcinoma">Basal cell adenocarcinoma</option>
<option value="Carcinosarcoma">Carcinosarcoma</option>
<option value="Mucinous adenocarcinoma, not otherwise specified">Mucinous adenocarcinoma, not otherwise specified</option>
<option value="Mucinous adenocarcinoma, intraductal papillary mucinous neoplasia subtype">Mucinous adenocarcinoma, intraductal papillary mucinous neoplasia subtype</option>
<option value="Mucinous adenocarcinoma, colloid / signet ring subtype">Mucinous adenocarcinoma, colloid / signet ring subtype</option>
<option value="Sclerosing microcystic adenocarcinoma">Sclerosing microcystic adenocarcinoma</option>
<option value="Lymphoepithelial carcinoma">Lymphoepithelial carcinoma</option>
<option value="Myoepithelial carcinoma">Myoepithelial carcinoma</option>
<option value="Sebaceous adenocarcinoma">Sebaceous adenocarcinoma</option>
<option value="Sialoblastoma">Sialoblastoma</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Neuroendocrine carcinoma :</label>
</td>
<td>
<select class="element select large" ID="A20">
<option value=""></option>
<option value="Neuroendocrine tumor, grade 1"><label >Neuroendocrine tumor, grade 1</label></option>
<option value="Neuroendocrine tumor, grade 2"><label >Neuroendocrine tumor, grade 2</label></option>
<option value="Neuroendocrine tumor, grade 3"><label >Neuroendocrine tumor, grade 3</label></option>
<option value="Neuroendocrine carcinoma, small cell type"><label >Neuroendocrine carcinoma, small cell type</label></option>
<option value="Neuroendocrine carcinoma, large cell type"><label >Neuroendocrine carcinoma, large cell type</label></option>
<option value="Combined (or composite) neuroendocrine carcinoma with (specify types):"><label >Combined (or composite) neuroendocrine carcinoma with (specify types):</label></option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Other histologic type :</label>
</td>
<td>
<select class="element select large" ID="A21">
<option value=""></option>
<option value="Mucosal melanoma"><label >Mucosal melanoma</label></option>
<option value="Carcinoma, type cannot be determined"><label >Carcinoma, type cannot be determined</label></option>
<option value="Other histologic type not listed (specify):"><label >Other histologic type not listed (specify):</label></option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- <a href=".\cap\Cancer-Protocols-2023-06-Update\Head and Neck Protocol Folder\HN.Oral_4.2.0.0.REL_CAPCP.pdf#page=19" target="_blank">Histologic grade</a> :</label>
</td>
<td>
<select class="element select large" ID="A22">
<option value=""></option>
<option value="G1: Well differentiated">G1: Well differentiated</option>
<option value="G2: Moderately differentiated">G2: Moderately differentiated</option>
<option value="G3: Poorly differentiated">G3: Poorly differentiated</option>
<option value="GX: Cannot be assessed">GX: Cannot be assessed</option>
<option value="Other (specify):">Other (specify):</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- <a href=".\cap\Cancer-Protocols-2023-06-Update\Head and Neck Protocol Folder\HN.Oral_4.2.0.0.REL_CAPCP.pdf#page=19" target="_blank">Grade/Intrinsic biologic potential</a>:</label>
</td>
<td>
<select class="element select large" ID="A76">
<option value=""></option>
<option value="Not applicable">Not applicable</option>
<option value="Low">Low</option>
<option value="Intermediate">Intermediate</option>
<option value="High / High-grade transformation">High / High-grade transformation</option>
<option value="Cannot be assessed">Cannot be assessed</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- <a href=".\cap\Cancer-Protocols-2021-11-Update\HN.Oral_4.1.1.0.REL_CAPCP.pdf#page=17" target="_blank">Depth of Invasion (DOI, mm)</a>:</label>
</td>
<td>
<input type="text" class="element text large" ID="A59" size="10">
</td>
</tr>
<tr>
<td>
<label class=""> + Tumor extension :</label>
</td>
<td>
<input type="text" class="element text large" ID="A23" size="45">
</td>
</tr>
<tr>
<td>
<label class="description">- Lymphatic and/on vascular invasion: </label>
</td>
<td>
<select class="element select large" ID="A24">
<option value=""></option>
<option value="Not identified">Not identified</option>
<option value="Present">Present</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- <a href=".\cap\Cancer-Protocols-2023-06-Update\Head and Neck Protocol Folder\HN.Oral_4.2.0.0.REL_CAPCP.pdf#page=18" target="_blank">Perineural invasion</a> : </label>
</td>
<td>
<select class="element select large" ID="A25">
<option value=""></option>
<option value="Not identified">Not identified</option>
<option value="Present">Present</option>
<option value="Present, intratumoral">Present, intratumoral</option>
<option value="Present, extratumoral">Present, extratumoral</option>
<option value="Present, intraneural, size of nerve">Present, intraneural, size of nerve</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class=""> + <a href=".\cap\Cancer-Protocols-2021-11-Update\HN.Oral_4.1.1.0.REL_CAPCP.pdf#page=19" target="_blank">Worst pattern of invasion (WPOI)</a> : </label>
</td>
<td>
<select class="element select large" ID="A26">
<option value=""></option>
<option value="WPOI 5 (tumor dispersion > or = 1 mm between tumor satellites, angiolymphatic invasion and extratumoral perineural invasion)">WPOI 5 (tumor dispersion > or = 1 mm between tumor satellites, angiolymphatic invasion and extratumoral perineural invasion)</option>
<option value="WPOI 1-4">WPOI 1-4</option>
</select>
</td>
</tr>
</table>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend><label class="description"><a href=".\cap\Cancer-Protocols-2021-11-Update\HN.Oral_4.1.1.0.REL_CAPCP.pdf#page=20" target="_blank">Surgical margins</a>: </label></legend>
<p>
<table border="1">
<col width="40%">
<tr>
<td>
<label class="description">- Surgical margins:</label>
</td>
<td>
<select class="element select large" ID="A27">
<option value=""></option>
<option value="Cannot be assessed">Cannot be assessed</option>
<option value="Uninvolved by invasive carcinoma, specify location and closest distance:">Uninvolved by invasive carcinoma, specify location and closest distance:</option>
<option value="Uninvolved by high grade dysplasia/ in situ disease, specify location and closest distance:">Uninvolved by high grade dysplasia/ in situ disease, specify location and closest distance:</option>
<option value="Involved by invasive carcinoma, specify location:">Involved by invasive carcinoma, specify location:</option>
<option value="Involved by high grade dysplasia/ in situ disease, specify location:">Involved by high grade dysplasia/ in situ disease, specify location:</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Tumor bed margins:</label>
</td>
<td>
<select class="element select large" ID="A28">
<option value=""></option>
<option value="Cannot be assessed">Cannot be assessed</option>
<option value="Uninvolved by invasive carcinoma, specify location and closest distance:">Uninvolved by invasive carcinoma, specify location and closest distance:</option>
<option value="Uninvolved by high grade dysplasia/ in situ disease, specify location and closest distance:">Uninvolved by high grade dysplasia/ in situ disease, specify location and closest distance:</option>
<option value="Involved by invasive carcinoma, specify location:">Involved by invasive carcinoma, specify location:</option>
<option value="Involved by high grade dysplasia/ in situ disease, specify location:">Involved by high grade dysplasia/ in situ disease, specify location:</option>
</select>
</td>
</tr>
</table>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class="description"> <a href=".\cap\Cancer-Protocols-2021-11-Update\HN.Oral_4.1.1.0.REL_CAPCP.pdf#page=22" target="_blank">Lymph nodes examination</a>: </label></legend>
<p>
<table border="1">
<col width="60%">
<tr>
<td>
<label class="description">- Number of regional lymph nodes examined:</label>
</td>
<td>
<input type="text" class="element text large" ID="A29" size="10">
</td>
</tr>
<tr>
<td>
<label class="description">- Number of lymph nodes involved:</label>
</td>
<td>
<input type="text" class="element text large" ID="A30" size="10">
</td>
</tr>
<tr>
<td>
<label class="description">- Extranodal extension (ENE) :</label>
</td>
<td>
<select class="element select large" ID="A31">
<option value=""></option>
<option value="Not identified">Not identified</option>
<option value="Present, distance from capsule (mm): (> 2 mm, ENEma)">Present, distance from capsule (mm): (> 2 mm)</option>
<option value="Present, distance from capsule (mm): (< or = 2 mm, ENEmi)">Present, distance from capsule (mm): (< or = 2 mm)</option>
<option value="Present, distance from capsule (mm): (< 1 mm)">Present, distance from capsule (mm): (< 1 mm)</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Size of largest metastatic deposit (mm), specify site:</label>
</td>
<td>
<input type="text" class="element text large" ID="A32" size="20">
</td>
</tr>
<tr>
<td>
<label class="description">- Size of largest lymph node involved (mm), specify site:</label>
</td>
<td>
<input type="text" class="element text large" ID="A33" size="20">
</td>
</tr>
<tr>
<td>
<label class="description">- Laterality:</label>
</td>
<td>
<select class="element select large" ID="A34">
<option value=""></option>
<option value="Ipsilateral (including midline)">Ipsilateral (including midline)</option>
<option value="Contralateral">Contralateral</option>
<option value="Bilateral">Bilateral</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
</table>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class="description"> Distant Metastasis: </label></legend>
<input class="element checkbox" type="checkbox" id="A67" value=" - Not applicable"><label class="choice" >Not applicable</label>
<input class="element checkbox" type="checkbox" id="A68" value=" - Not identified"><label class="choice" >Not identified</label>
<input class="element checkbox" type="checkbox" id="A69" value=" - Non-regional lymph node(s) (specify):"><label class="choice" >Non-regional lymph node(s) (specify):</label>
<input class="element checkbox" type="checkbox" id="A70" value=" - Lung (specify):"><label class="choice" >Lung (specify):</label>
<input class="element checkbox" type="checkbox" id="A71" value=" - Liver (specify):"><label class="choice" >Liver (specify):</label>
<input class="element checkbox" type="checkbox" id="A72" value=" - Bone (specify):"><label class="choice" >Bone (specify):</label>
<input class="element checkbox" type="checkbox" id="A73" value=" - Brain (specify):"><label class="choice" >Brain (specify):</label>
<input class="element checkbox" type="checkbox" id="A74" value=" - Other (specify):"><label class="choice" >Other (specify):</label>
<input class="element checkbox" type="checkbox" id="A75" value=" - Cannot be determined: "><label class="choice" >Cannot be determined: </label>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class="description"> <a href=".\cap\Cancer-Protocols-2021-11-Update\HN.Oral_4.1.1.0.REL_CAPCP.pdf#page=26" target="_blank">Pathologic Stage Classification (AJCC 8e) for carcinoma</a>:</label></legend>
<p>
<table border="1">
<col width="40%">
<tr>
<td valign="top">
<label class="description"> - TNM Descriptors:</label>
</td>
<td>
<input class="element checkbox" type="checkbox" id="A35" value=" m (multiple primary tumors) "><label class="choice">m (multiple primary tumors)</label>
<input class="element checkbox" type="checkbox" id="A36" value=" r (recurrent) "><label class="choice">r (recurrent)</label>
<input class="element checkbox" type="checkbox" id="A37" value=" y (post treatment) "><label class="choice">y (post treatment)</label>
</tr>
<tr>
<td>
<label class="description"> - Primary tumor (pT):</label>
</td>
<td>
<select class="element select large" ID="A38">
<option value=""></option>
<option value=" - pT not assigned (cannot be determined based on available pathological information)">pT not assigned (cannot be determined based on available pathological information)</option>
<option value=" - pT0: No evidence of primary tumor">pT0: No evidence of primary tumor</option>
<option value=" - pTis: Carcinoma in situ">pTis: Carcinoma in situ</option>
<option value=" - pT1: Tumor < or = 2 cm with depth of invasion (DOI) < or = 5 mm">pT1: Tumor < or = 2 cm with depth of invasion (DOI) < or = 5 mm</option>
<option value=" - pT2: Tumor < or = 2 cm with DOI > 5 mm; OR tumor > 2 cm and < or = 4 cm with DOI < or = 10 mm">pT2: Tumor < or = 2 cm with DOI > 5 mm; OR tumor > 2 cm and < or = 4 cm with DOI < or = 10 mm</option>
<option value=" - pT3: Tumor > 2 cm and < or = 4 cm with DOI >10 mm; OR tumor > 4 cm with DOI < or = 10 mm">pT3: Tumor > 2 cm and < or = 4 cm with DOI >10 mm; OR tumor > 4 cm with DOI < or = 10 mm</option>
<option value=" - pT4: Moderately advanced or very advanced local disease">pT4: Moderately advanced or very advanced local disease</option>
<option value=" - pT4a: Moderately advanced local disease: Tumor > 4 cm with DOI > 10 mm; OR tumor invades adjacent structures only (eg, through cortical bone of the mandible or maxilla or involves the maxillary sinus or skin of the face)">pT4a: Moderately advanced local disease: Tumor > 4 cm with DOI > 10 mm; OR tumor invades adjacent structures only (eg, through cortical bone of the mandible or maxilla or involves the maxillary sinus or skin of the face)</option>
<option value=" - pT4b: Very advanced local disease: Tumor invades masticator space, pterygoid plates, or skull base, and/or encases the internal carotid artery">pT4b: Very advanced local disease: Tumor invades masticator space, pterygoid plates, or skull base, and/or encases the internal carotid artery</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description"> - Regional lymph nodes (pN):</label>
</td>
<td>
<select class="element select large" ID="A39">
<option value=""></option>
<option value=" - pN not assigned (no nodes submitted or found)">pN not assigned (no nodes submitted or found)</option>
<option value=" - pN not assigned (cannot be determined based on available pathological information)">pN not assigned (cannot be determined based on available pathological information)</option>
<option value=" - pN0: No regional lymph node metastasis">pN0: No regional lymph node metastasis</option>
<option value=" - pN1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(-)">pN1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(-)</option>
<option value=" - pN2 (subgroup cannot be determined)">pN2 (subgroup cannot be determined)</option>
<option value=" - pN2a: Metastasis in single ipsilateral node 3 cm or smaller in greatest dimension and ENE(+); or a single ipsilateral node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-)">pN2a: Metastasis in single ipsilateral node 3 cm or smaller in greatest dimension and ENE(+); or a single ipsilateral node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-)</option>
<option value=" - pN2b: Metastases in multiple ipsilateral nodes, none larger than 6 cm in greatest dimension and ENE(-)">pN2b: Metastases in multiple ipsilateral nodes, none larger than 6 cm in greatest dimension and ENE(-)</option>
<option value=" - pN2c: Metastases in bilateral or contralateral lymph node(s), none larger than 6 cm in greatest dimension and ENE(-)">pN2c: Metastases in bilateral or contralateral lymph node(s), none larger than 6 cm in greatest dimension and ENE(-)</option>
<option value=" - pN3 (subgroup cannot be determined)">pN3 (subgroup cannot be determined)</option>
<option value=" - pN3a: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-)">pN3a: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-)</option>
<option value=" - pN3b: Metastasis in a single ipsilateral node larger than 3 cm in greatest dimension and ENE(+); or multiple ipsilateral, contralateral or bilateral nodes any with ENE(+); or a single contralateral node of any size and ENE(+)"> pN3b: Metastasis in a single ipsilateral node larger than 3 cm in greatest dimension and ENE(+); or multiple ipsilateral, contralateral or bilateral nodes any with ENE(+); or a single contralateral node of any size and ENE(+)</option>
</select>
</td>
</tr>
<tr>
<td valign="top" rowspan="2">
<label class="description"> - Distant metastasis (pM):</label>
</td>
<td>
<select class="element select large" ID="A40">
<option value=""></option>
<option value=" - Not applicable - pM cannot be determined from the submitted specimen(s)">Not applicable - pM cannot be determined from the submitted specimen(s)</option>
<option value=" - pM1: Distant metastasis">pM1:Distant metastasis</option>
</select>
</td>
</tr>
<!--
<tr>
<td>
- Specify site(s), if known:
<input type="text" class="element text small" ID="A41" size="35">
</td>
</tr>
-->
</table>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class="description"> Pathologic Stage Classification (AJCC 8e) for mucosal melanoma:</label></legend>
<p>
<table border="1">
<col width="40%">
<tr>
<td valign="top">
<label class="description"> - TNM Descriptors:</label>
</td>
<td>
<input class="element checkbox" type="checkbox" id="A42" value=" m (multiple primary tumors) "><label class="choice">m (multiple primary tumors)</label>
<input class="element checkbox" type="checkbox" id="A43" value=" r (recurrent) "><label class="choice">r (recurrent</label>
<input class="element checkbox" type="checkbox" id="A44" value=" y (post treatment) "><label class="choice">y (post treatment)</label>
</td>
</tr>
<tr>
<td>
<label class="description"> - Primary tumor (pT):</label>
</td>
<td>
<select class="element select large" ID="A45">
<option value=""></option>
<option value=" - pT3: Tumors limited to the mucosa and immediately underlying soft tissue, regardless of thickness or greatest dimension; for example, polypoid nasal disease, pigmented or nonpigmented lesions of the oral cavity, pharynx, or larynx">pT3: Tumors limited to the mucosa and immediately underlying soft tissue, regardless of thickness or greatest dimension; for example, polypoid nasal disease, pigmented or nonpigmented lesions of the oral cavity, pharynx, or larynx</option>
<option value=" - pT4: Moderately advanced or very advanced disease">pT4: Moderately advanced or very advanced disease</option>
<option value=" - pT4a: Moderately advanced disease: Tumor involving deep soft tissue, cartilage, bone, or overlying skin">pT4a: Moderately advanced disease: Tumor involving deep soft tissue, cartilage, bone, or overlying skin</option>
<option value=" - pT4b: Very advanced disease: Tumor involving brain, dura, skull base, lower cranial nerves (IX, X, XI, XII), masticator space, carotid artery, prevertebral space, or mediastinal structures">pT4b: Very advanced disease. Tumor involving brain, dura, skull base, lower cranial nerves (IX, X, XI, XII), masticator space, carotid artery, prevertebral space, or mediastinal structures</option>
</select>
</td>
</tr>
</p>
<tr>
<td>
<label class="description"> - Regional lymph nodes (pN):</label>
</td>
<td>
<select class="element select large" ID="A46">
<option value=""></option>
<option value=" - pN not assigned (no nodes submitted or found)">pN not assigned (no nodes submitted or found</option>
<option value=" - pN not assigned (cannot be determined based on available pathological information)">pN not assigned (cannot be determined based on available pathological information)</option>
<option value=" - pN0: No regional lymph node metastasis">pN0: No regional lymph node metastasis</option>
<option value=" - pN1: Regional lymph node metastases present">pN1: Regional lymph node metastases present</option>
</select>
</td>
</tr>
</p>
<tr>
<td valign="top" rowspan="2">
<label class="description"> - Distant metastasis (pM): </label>
</td>
<td>
<select class="element select large" ID="A47">
<option value=""></option>
<option value=" - Not applicable - pM cannot be determined from the submitted specimen(s)"> Not applicable - pM cannot be determined from the submitted specimen(s)</option>
<option value=" - pM1: Distant metastasis">pM1:Distant metastasis</option>
</select>
</td>
</tr>
</p>
<!--
<tr>
<td>
- Specify site(s), if known:
<input type="text" class="element text small" ID="A48" size="35">
</td>
</tr>
-->
</table>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">