GPCRchimeraDB

Main repository of the database GPCRchimeraDB (https://www.bio2byte.be/gpcrchimeradb/).

Format the Data

In the folder Notebooks, the following Jupyter notebooks are available:

• Format a chimera's data: Identify parents, cutting sites, and mutations based on its sequence.
• Generate entry file for chimeric GPCRs.
• Generate entry file for natural GPCRs.

The Data

Available on Zedodo :

• Entry files (JSON, 1 per entry).
• FASTA sequences.
• Structures (PDB, AF2, AF2 MS, ESMFold, dssp, mapping).
• Master alignment (MSA).
• Activation state structures (GPCRdb).
• Classification.
• G-protein and B-arrestin coupling (GPCRdb).
• Endogenous ligands (GPCRdb).
• Variants (GPCRdb).
• Scientific to common names organisms (UniProt).

The Database

Explore your favorite chimeric or natural GPCR at the sequence, structural, and biophysical levels and design new chimeras!

Visit GPCRchimeraDB: https://www.bio2byte.be/gpcrchimeradb/.

The Database's Documentation

Visit GPCRchimeraDB's documentation: https://gpcrchimeradb-docs.readthedocs.io/en/latest/index.html.

Citation

@article{CRAUWELS2025169164,
title = {GPCRchimeraDB: A database of chimeric G protein-coupled receptors (GPCRs) to assist their design},
journal = {Journal of Molecular Biology},
pages = {169164},
year = {2025},
issn = {0022-2836},
doi = {https://doi.org/10.1016/j.jmb.2025.169164},
author = {Charlotte Crauwels and Adrián Díaz and Wim Vranken},
}

Contact Us

bio2byte@vub.be

Shield:

This work is licensed under a Creative Commons Attribution 4.0 International License.