GEMINI: Genetic Evaluation of Multimorbidity towards INdividualisation of Interventions.

We are studying links between 72 long-term conditions that could help improve interventions and treatments, using data from:

• two large population-representative primary care datasets: CPRD and SIDIAP,
• up to three sources of genetics data: UK Biobank, FinnGen, and multiple consortium meta-analyses (where available).

⭐ Our seminal paper is available! If you use these resources please cite the preprint and resource release version:

Murrin et al. (2024) A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care data. medRxiv. https://doi.org/10.1101/2024.05.13.24307009

Resources available:

• 📚 Harmonised diagnostic codes for each long-term condition ascertained in GEMINI.
• 📦 R package {partialLDSC} to estimate partial genetic correlations from GWAS results (preprint coming soon!)