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Gene expansions contributing to human brain evolution

This repository contains all scripts and intermediate files for all the analyses included in reference pending.

The analyses were divided based on the sections of the manuscript as follows:

  • Section I: Identification of human gene duplications in T2T-CHM13
  • Section II: Connecting genetic variation of duplicated genes with neural traits
  • Section III: Duplicated gene expression in the developing human brain
  • Section IV: Modeling functions of duplicated genes in brain development
  • Section V: Genetic variation of candidate genes important in neurodevelopment
  • Section VI: Duplicated gene functions modeled using zebrafish
  • Section VII: Novel human-specific genes impacting neurodevelopment

Each Section folder includes all scripts and files necesseary for running them. Raw sequencing files are found in ENA project PRJEB82358.

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