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Multi-cell population modelling predicts metabolic activity of midbrain organoids

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MidbrainOrganoid_Miro1_scMetabMod

Multi-cell population modelling predicts metabolic activity of midbrain organoids

Model building was done with scFASTCORMICS, see: scFASTCORMICS

Paper: Miro1 mutation leads to metabolic maladaptation resulting in Parkinson’s disease-associated dopaminergic neuron loss

Alise Zagare1*, Thomas Sauter2*, Kyriaki Barmpa1, Maria Pacheco2, Rejko Krüger3,4, Jens Christian Schwamborn1*#, Claudia Saraiva1#

Affiliations

  1. Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 2, place de l’Université, L-4365 Esch-sur-Alzette, Luxembourg.
  2. Systems Biology group, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 2, place de l’Université, L-4365 Esch-sur-Alzette, Luxembourg.
  3. Translational Neuroscience, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 2, place de l’Université, L-4365 Esch-sur-Alzette, Luxembourg.
  4. Transversal Translational Medicine, Luxembourg Institute of Health (LIH), 1 A-B rue Thomas Edison, L-1445 Strassen, Luxembourg

*Equal contribution

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Multi-cell population modelling predicts metabolic activity of midbrain organoids

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